1. Fragment of immunoglobulin prepared by papain treatment. Fab fragments (45 kD) consist of one light chain linked through a disulphide bond to a portion of the heavy chain, and contain one antigen binding site. They can be considered as univalent antibodies.
2. Fragment (90 kD) of an immunoglobulin produced by pepsin treatment. These fragments have two antigen combining sites and contain two light chains and two variable region heavy chains plus one constant region domain in each heavy chain. The fragment is divalent but lacks the complement-fixing (Fc) domain.

Dictionary of molecular biology. 2004.

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